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The most noticeable histologic finding was the presence of an orthoparakeratotic column that filled the infundibulum and protruded above the epidermal surface

Disclosures: Andrea Mospan: Nothing to Disclose, Breda Munoz: Nothing to Disclose, Heather Morris: Nothing to Disclose, Aarth Sheth: Nothing to Disclose, Rakesh Luthra: Nothing to Disclose 1080 VALIDATION AND EPIDEMIOLOGIC DEFINITION OF THE NOVEL STEATOTIC LIVER DISEASE NOMENCLATURE IN A NATIONAL COHORT WITH CIRRHOSIS Catherine Mezzacappa 1 Pedro Ochoa-Allemant 2 Marina Serper 3 Tamar Taddei 1 Binu John 4 David Kaplan 2 Nadim Mahmud 5 , 1 Yale University, 2 University of Pennsylvania, 3 University of Pennsylvania Health System, 4 University of Miami, 5 Hospital of the University of Pennsylvania Background: Novel steatotic liver disease (SLD) definitions were introduced in 2023 with a diagnostic algorithm based on the presence of cardiometabolic risk factors (CMRFs) and thresholds for alcohol exposure to define metabolic dysfunction-associated SLD (MASLD), alcohol-associated liver disease (ALD), and metabolic and alcohol-associated liver disease (MetALD)

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Control experiment wells were either on the same plate or a separate plate in the same shaker incubator for 1 h at 37 C, and each well contained 10 L of PBS with 90 L of DBCO-labeled cell culture (both IPTG-induced and non-induced cells), in triplicate