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Despite a normal or near-normal ejection fraction, these patients have diastolic dysfunction where the heart's relaxation and filling phases are impaired

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For example, studies performed in murine J774A.1 macrophages showed that TMAO induced stress and led to increased protein expression of GRP94 and HSP70, which may participate in the abnormal activation of macrophages involved in foam cell formation (Mohammadi et al., 2018)

Novel techniques, such as single-cell sequencing, could be applied to further clarify the metabolic shift in each cell types and patterns of cellcell cross talk in different cancers