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"By itself, the Blue Zone theory is not regarded as strong science," says Dr

Inhibiting NNMT with 5-Amino-1MQ preserves intracellular NAD+ levels, which supports mitochondrial function and has been shown in rodent models to reduce adiposity and improve insulin sensitivity

We subsequently determined whether IPA enhances ISC proliferation in organoid assays, determining that no differences in colonic organoid formation and development were present between Veh- and IPA-treated mice at D0, indicating that IPA does not affect ISC proliferation ex vivo in the absence of DSS-induced injury