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Design, synthesis and antitumor activity of novel D-glucuronic acid derivatives

doi: 10.1371/journal.pone.0080148 48 ShapiroSD

Arginase one could deplete circulating arginine, a substrate that is required by endothelial nitric oxide synthase (eNOS) for NO production ( The second group of RBC intracellular contents activates platelets

Further, in certain embodiments, mobilization (for example, mobilization with GM-CSF) and conditioning regimens can be used to create a condition in a subject wherein repopulation, recirculation, regeneration, and/or expansion of particular cell types is favored, especially during a defined window of time following therapy