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Uric acidlowering drugs in diabetes Considering UA as a target for prevention/management of diabetes is still premature and needs to be evaluated in clinical trials

However, its use was associated with an increased risk of infections and cancer, similar to other biologics, as well as an increase in all cause mortality in patients 50 years and older with at least one CV risk factor (Lee et al, 2014

doi: 10.3390/ijms25115874 159

In BV-2 cells treated with fluoride, SOD levels decreased, while those of MDA, ROS, superoxide anions (O 2 ), and NOS significantly increased in a dose-dependent manner (Shuhua et al., 2012)