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This mutation also results in a CPT1A protein that is less sensitive for the inhibitory effect of malonyl-CoA on CPT1A under fed conditions, resulting in a 34 times higher activity of CPT1A compared to wild type [91,92,93]

10.32598/IJMTFM.V12I1.35883 101 RamirezS

Abstract Trimethylamine N-oxide (TMAO), a key metabolite derived from the gut microbial metabolism of choline, has recently been implicated as a significant contributor to the development of several chronic diseases, including diabetes, cardiovascular disease, and chronic kidney disease

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