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However, under excessive or repetitive strain, calcium overload through TRPV4 and Piezo1 triggers activation of NADPH oxidase (NOX) enzymes and mitochondrial ROS production, leading to oxidative damage, inflammatory gene expression, and cell apoptosis (Swain and Liddle, 2021)

We investigated three distinct inhibitors (IKE, CB-839, and polydatin), each targeting distinct components of the antioxidant machinery, to assess their potential to enhance 5-FU efficacy

Argolini LM, Frontini G, Elefante E, Saccon F, Binda V, Tani C, Scotti I, Carli L, Gatto M, Esposito C, Gerosa M (2021) Multicentric study comparing cyclosporine, mycophenolate mofetil and azathioprine in the maintenance therapy of lupus nephritis: 8 years follow up