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In regard to musculoskeletal problems, cortisone injections are performed in order to reduce or even eliminate pain associated with a variety of disorders, such as: Bursitis (most commonly subacromial and trochanteric bursitis) Arthritis (any joint may be injected, including joints of the spine) Nerve pain (most commonly for sciatica and carpal tunnel) Tendinitis and Tenosynovitis (such as plantar fasciitis, trigger finger, DeQuervains tenosynovitis, Tennis and Golfers elbow) Other miscellaneous conditions where inflammation is a contributor to the pain, (frozen shoulder/ adhesive capsulitis, Mortons neuroma, ganglion cyst injections and Dupuytrens contracture)

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At the infection site, the low intracellular calcium concentration triggers the release mechanism of the nanocrystals, allowing the drug to be directly released inside the cells, thereby avoiding systemic tissue damage caused by Amphotericin B (Boulware et al., 2023)