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127 , 128 These reactions are considered intermediate steps in DNA demethylation, but interestingly, 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine also exhibit replication dependent dilution and each has specific reader proteins, 129 131 suggesting that these modifications may be functional during development

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Peptide therapy with Dihexa may also be used to manage depression and to improve short and long-term memory

A high level of DNA methylation is associated with the silence of TSG (Akhavan-Niaki and Samadani, 2013)