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Considering all this, its not too surprising that high levels of homocysteine have been linked to many chronic neurodegenerative and neuropsychiatric diseases, including: Depression (105-111) Dementia, Alzheimers disease , cognitive impairment/dysfunction/decline (119-133, 143) Headaches and migraines (112-118, 148) Hearing loss (136-137) Brain atrophy (134, 144, 151) Parkinsons disease (145) Stroke (154-155) Postpartum depression (135) Postmenopausal mental decline (146) Schizophrenia and other affective disorders (147, 153, 156) Alcoholism (149) Multiple sclerosis (158-161) People with nutritional deficiencies and MTHFR gene mutation are at an increased risk of high homocysteine levels

10.1158/0008-5472.CAN-17-3454 72 MashimaT.SeimiyaH.TsuruoT

Moreover, accumulation of homocysteine for longer periods is thought to be involved in the failure of -amyloid clearance and damage to the blood brain barrier, which develops into cerebrovascular dysfunction, leading to AD development [65]

General procedure and design This study used a within-subject design including screening, and two baseline assessments before treatment initiation (pretreatment), and one assessment at posttreatment