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Microbiota-targeted interventions, including probiotics, prebiotics, synbiotics, and dietary modulation, have demonstrated potential to improve microbial composition, alleviate systemic inflammation, enhance thyroid hormone utilization, and reduce autoantibody levels

A further methodological concern is that widely used models, particularly caerulein-based paradigms, capture synchronized acinar-cell stress and early mitochondrial injury very effectively, but they incompletely reproduce the full spectrum of necrotizing, biliary, hypertriglyceridemic, post-ERCP, or alcohol-associated human disease

Surgery 117, 226231

& Stothard, P