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Herein, we present a versatile method for the direct functionalisation of readily available amino-modified oligonucleotides (AONs), where a 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones (5HP2O) Michael acceptor is directly formed in a rapid and efficient manner on a free primary amine

Mar M, Morales A, Colell A, Garca-Ruiz C, Fernndez-Checa JC. Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal. 2009;11(11):2685-2700. doi:10.1089/ARS.2009.2695