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Regarding LINGO1 rs9652490 and LINGO1 rs11856808, previous meta-analyses have reported association with ET [ 34 , 141 , 142 ]

Ethics approval and consent to participate This study was approved by the ethical committee on the use of animals for research, Department of Biotechnology, Federal University of Technology, Owerri, Nigeria in line with strict compliance with standard laboratory principles of animal care of the United States National Institute of Health (NIH, 1978)

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It is suggested that the activated BZ and NFX (and their metabolites), through direct binding to trypanothione (T[SH] 2 , N 1 ,N 8 -bisglutathionylspermidine) and GSH, make these antioxidants unavailable for the parasite's defense (Maya et al., 1997