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A single protein, arsenic (+3 oxidation state) methyltransferase (AS3MT), catalyzes both reduction and methylation reactions for As shown in Figure 2

Indian J Otolaryngol Head Neck Surg

The surplus of ROS represents a trigger for programmed cell death processes and promotes the release of pro-inflammatory cytokines, which are also responsible for further increasing ROS levels, thus perpetuating the pathophysiological process of AD