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Tuberculosis primarily affects the lungs, but can affect other sites in the body, when the mycobacteria enter the lung tissue, antigen presenting cells release interleukins (IL)-6 and -12, followed by the production of interferon gamma (IFN-), IL-23, IL-1 and IL-17 by lymphocytes, leading to activation of macrophages, which in turn produce tumor necrosis factor-alpha (TNF-), and promote intracellular mycobacterial clearance

Type 2 diabetes, body weight, sex, baseline fat, and cardiac responsiveness all reshape the output

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Notably, a post-injury course that is not reversed always presents a devastating progression