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Major clinical indications include glaucoma, pharmacologic induction of miosis, presbyopia, and xerostomia (dry mouth)

Although these are rough estimates that rest upon assumptions about the relative rates and ability to detect DILI between different drugs (and between the US and Iceland), the EID provides informative rates for these rare events and likely explains why the risk of DILI may be missed in registration trials of new drugs which may enroll fewer than 1,000-3,000 patients