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10.1016/0006-2952(92)90026-F 85 EsazadehK.Ezzati Nazhad DolatabadiJ.AndishmandH.Mohammadzadeh-AghdashH.MahmoudpourM.Naemi KermanshahiM.et al (2024)

To examine the requirement for MEIS1-2 in cardiomyocyte differentiation, we compared transcriptomes of wild-type and MEIS KO (two MEIS KO clones, KO1 and KO2) at two stages, corresponding to early (d5, shortly after the onset of MEIS1 transcription) and late (d7) cardiac progenitors

In addition, the kinetics of these systems were considerably improved by PEGylation reducing their systemic clearance and increasing targeting efficiency (by application of selective/specific targeting ligands)