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10.1111/anu.12403 [DOI] [PMC free article] [PubMed] [Google Scholar] Thieme R., Kurz S., Kolb M., Debebe T., Holtze S., Morhart M., et al

Conclusion: In the DDC acute cholangiopathy model, FXR agonists are protective through STAT3 signaling, M1 to M2 macrophage polarization, and by inducing fatty acid oxidation, suggesting STAT3 as a potential therapeutic target in PSC