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Moving forward, the results of the phase 3 SURPASS clinical trial program demonstrated that tirzepatide was as effective and safe as other anti-diabetic agents, such as semaglutide and dulaglutide (SURPASS-2) (SURPASS J-mono), long-acting insulin analogs (degludec and glargine) (SURPASS-3,4), and placebo (SURPASS-1) (SURPASS-5), in managing T2DM diabetes [65,66,67,68,69]

Another drug simvastatin, commonly used to treat high cholesterol, has also been shown to alter the gut microbiota to provide a therapeutic advantage against radiation-induced injury in mice ( Microbiome Biomarkers as Biodosimeters In the case of a radiation mass casualty incident, H-ARS and GI-ARS subsyndromes will pose an immediate public health risk ( 50/60 ) is 3.254 Gy in the absence of supportive care but can be increased to 67 Gy with appropriate medical interventions (Waselenko et al., 2004)

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