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The FDA noted in the warning, Using contaminated eye drops could result in a range of ocular infections, from minor to serious vision-threatening infections which could progress in some cases to a life-threatening infection. The Sarasota manufacturer confirmed that the drug components were imported from LightEyez and added that a malfunctioning water system resulted in the use of unfiltered municipal water in (the) ophthalmic drug product. The FDA warning letter also expressed concerns that the company website notes that the drug containers may leak during shipping, and in addition instructs consumers to clear blockages in the droppers by inserting a foreign object into the dropper tip nozzle and/or remove the dropper tip to clear a blockage, which risks contamination of (the) ophthalmic drug products with foreign particulate matter and/or microorganisms. ( The drops lighten eye color by inhibiting the production of melanin, which gives pigmentation to the iris

Mitochondrial stress accelerates and amplifies these pathological processes, creating a self-reinforcing cycle of oxidative injury, impaired bioenergetics, and cardiometabolic dysfunction (1-2)

In terms of its purity and impurity profile, manufacturers should perform consistently robust testing, such as with high-performance liquid chromatography

doi: 10.1021/acschembio.9b00211 109 IyamuIDHuangR