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The combination of nave T-cell activation and rapid Gln uptake depends on SLC1A5 (also known as ASCT2), a deficiency of which reduces the differentiation of Th1 cells in vivo , impairs Th1 induction, and attenuates inflammatory T-cell responses (49)

A phase 1 study of the DOT1L inhibitor, pinometostat (EPZ-5676), in adults with relapsed or refractory leukemia: safety, clinical activity, exposure and target inhibition Blood 126 , 2547 (2015)