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The NIH estimates that 10 to 30 percent of adults over 50 have some degree of B12 malabsorption

Patients with a prior history of serious gastrointestinal adverse events and other known risk factors that are associated with peptic ulcer disease ( alcoholism, smoking) are at increased risk

The rest of this article breaks down their actual biological targets, clinical trial outcomes, side effect profiles, and which research applications each one genuinely serves