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Recent studies using intranasal injections of Mn at 30 days and 90 days are good models of chronic overexposure of Mn through inhalation

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Safety and side effects: A meta-analysis of multiple studies in COPD patients showed no significant adverse effects at doses ranging from 600 mg to 3g/day.[ref] Studies in healthy adult athletes go up to 20g/day (not recommending this, just including it for safety).[ref] Conversely, in Parkinsons patients, there was a high number of adverse events at 6g/day of NAC

But research continues on other forms of PrEP, and they might become available in the not-too-distant future