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The process of PD fluids heat sterilization leads to the formation of glucose degeneration products (GDP) which promote generation of advanced glycation end-products (AGEs) and pro-oxidants [17,18,19,20]

These results suggest that the increased glucose uptake and excretion (glucotonic effect) in the distal intestine and colon following metformin administration indicate that metformin acts at these regions to exert its blood glucose-lowering effects

(150) have shown that in ovo delivery of vitamin C on e11 resulted in changes in the mRNA expression of genes related to DNA methylation such as DNA methyltransferase, DNA demethylation, growth arrest, and DNA-damage inducible protein beta, thymine-DNA glycosylase, and methyl-CpG-binding domain protein 4 at day 21 or 42 post-hatch

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