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Here, for the first time, our work clarified the detailed mechanism on how TRPM7 participates in pyroptosis and epileptogenesis, and how targeting TRPM7 may pave the way for a new generation of drugs to treat SE and other neurological conditions, among which neuronal pyroptosis is a hallmark pathology

These therapies directly target tissue damage and widespread pain, aiming to reduce inflammation, modulate the immune system, and promote genuine healing instead of just masking symptoms

However, both drugs can cause stomach discomfort, diarrhea, and constipation, especially during dose escalation

Additionally, conventional antidepressants display remarkable limitations, such as the delayed onset of action, low response rates, and relapse following medication discontinuation, impeding treatment compliance in patients with depression (Sabella, 2018)