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c) TC = 32 mg/m 3 (6/24) (5/7) = 11.4 g/m 3 500 * 32 mg/m 3 is the LOAEL in the 2-year inhalation study on rats * (6/24) (5/7) is the conversion from 6 h/day and 5 days/week to continuous exposure * 500 is the uncertainty factor (10 for interspecies variation, 10 for intraspecies variation and 5 for use of a marginal effect rather than a no-observed-effect level)

The rats were maintained in an animal room with an air-conditioned barrier system at an ambient temperature of 25C 2C, relative humidity of 50% 10%, and a 12 h light/dark cycle

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Originally developed for type 2 diabetes, it has now been approved for weight loss due to its ability to significantly reduce body weight, improve insulin sensitivity, and lower cardiometabolic risks