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Supplementary Figure 4 Nrf2 is necessary for AKT2(E17K)-mediated stimulation of GSH biosynthesis and resistance to oxidative stress

Mild and occasional

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The proper functioning of GPX4, a member of the GPX family responsible for converting cytotoxic lipid hydroperoxides (L-OOH) into nontoxic lipid alcohols (L-OH), thus preventing the formation of lethal lipid ROS, is dependent on the indispensable cofactor GSH (45)