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Protein structure comparison showed that SsCm1 was obviously different from other Cms in three-dimensional structure, and molecular docking simulation revealed that SsCm1 showed less affinity with chorismate (binding energy = 2.1 kcal/mol) than ScAro7 (5.7 kcal/mol) (Supplementary Fig

These protective effects involve reduction of oxidative stress, anti-inflammatory effects through modulation of cytokine production, anti-apoptotic effects, improvement of cerebral blood flow, and preservation of mitochondrial function

425 In two separate preclinical trials, tranilast exhibited promising urate-lowering effects along with a reduction in inflammation associated with urate crystal deposition