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Paracrine senescence is predominantly mediated by SASP, through which senescent cells release a spectrum of inflammatory cytokines (e.g., IL-6, IL-1, TNF-), growth factors, and proteases

Given the significant impact of maternal age on reproductive outcomes and the emerging importance of these novel cell death pathways, strategies to enhance oocyte quantity and quality in women of advanced maternal age are of paramount importance in reproductive medicine

Afterwards, subsequent discoveries have identified increased lactylation in histone and non-histone proteins, particularly with the development of YnLac, an alkynyl-functionalized chemical reporter

Mohamed Yusoff AA, Mohd Khair SZN, Abd Radzak SM, Idris Z, Lee H-C