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The procedure to locate the voxel for the IFC was: (a) center the voxel at the first axial slice above the ventricles at the height of one third of the sagittal midline and at the width center of the left hemisphere, (b) from the sagittal view locate the center length of the voxel parallel to the inferior frontal sulcus and locate the length over the inferior frontal junction, and (c) from the coronal view, locate the top of the voxel parallel to the cortical surface

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These tumors contain a high percentage of infiltrating tumor-supporting cells with atypical proliferative and signaling capabilities associated with haploinsufficiency of neurofibromin from the germline mutation of NF1

A study of 200 adults with medically refractory epilepsy who were treated with brivaracetam found that 23% experienced at least a 50% reduction in seizure frequency [231]