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Although the peptide substrate PCa-5791 is rather specific for APC, this substrate is hydrolyzed in the presence of low nanomolar concentration of thrombin which might conceal the detection of APC generation in the activation mixture (see Supplementary Fig

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The end-target signals, often derived from injury or pathogens, focus neutrophil cytotoxic activity precisely on the relevant targets

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Nrf2, Nuclear factor erythroid2-related factor 2

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