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Although approximately 1 in 1500 patients exhibit signs of chronic liver injury in long-term prophylactic therapy, acute liver injury due to NFT is quite rare, with approximately 0.3 cases per 100,000 prescriptions (LiverTox 2020)

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Autophagy can be initiated under different conditions, typically starvation or nutrient deprivation, but also during oxidative stress, ER calcium depletion, decreased glycosylation and protein aggregate accumulation (Mizushima et al., 2004