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Acknowledgements The authors wish to acknowledge that this manuscript is derived in part from the doctoral dissertation titled Bio-Geochemistry of ovarian cancer: Role of selenium nanoparticles in treatment and copper isotopes in detection of ovarian cancer., completed by Benoit Toubhans under the supervision of R

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Alcohol and tobacco Heavy alcohol intake and smoking both stress the nervous system and bone marrow and can interfere with nutrient status

Furthermore, it is noteworthy that perfusion deficits often manifest before the appearance of clinical symptoms in neurodegenerative diseases (Korn 2008)