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The metabolic crosstalk between various cell types in the TME, combined with epigenetic regulation, creates a complex metabolic environment that promotes tumor growth, metastasis, and resistance to treatment[25, 26]

DIO2 is considered as primarily responsible for the local production of T3 inside cells and its presence has been detected in several locations, such as the pituitary gland and hypothalamus, cochlea, brown adipose tissue, bones, muscles, heart, and central nervous system

The Global Climate Shift Index (CSI-Global) maps the influence of climate change on daily average temperatures across the entire globe

Still, it is a pharmacodynamically expected consequence of glucagon agonism and represents a meaningful differentiator from tirzepatide