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Priorities for research include head-to-head evaluation of analogs in EMS models with integrated pharmacokineticpharmacodynamic mapping and iterative chemistry to lower promiscuous binding without compromising on-lesion potency

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It has been found that the ferroptosis inducer, erastin, irreversibly activates CHOP/PUMA within the p53 signaling pathway, thereby enhancing the sensitivity of tumor cells to apoptosis inducers and facilitating apoptosis (Hong et al., 2017)

sulindac, a NSAID, which inhibits COX-2 [54] and the anti-diabetic drug pioglitazone, which is an agonist of the peroxisome proliferator-activated receptor gamma with anti-inflammatory effects [55, 56]