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Research suggests that ER stress is associated with various lesions during AS and affects the disease course, which occurs in endothelial cells, VSMCs, and macrophages by integrating protein and lipid metabolism, cell death, and inflammatory responses (69)

Dietary antioxidants and other constituents, including those increasing the level of Nrf2, may also have beneficial effects

425,426 Additionally, IgG, IgM, and IgA autoantibodies against HSP60, HSP70, and HSP90 are significantly elevated in RA patients