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However, in the presence of 0.8 M F2 peptide inhibitor, the K m , K i and [I]/K i values were determined as 0.38 mM, 1.53 M and 0.52, respectively

Therefore, preserving the intestinal barrier and modulating the core signaling pathways represent the key strategic approaches to interrupt this lethal cascade

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While the ligands IGF-1, IGF-2, and insulin have the highest affinity towards their cognate receptors, they can also bind and activate other receptors in the family (for instance IGF-1 can bind IGF-1R and InsR/IGF-1R, IGF-2 can bind IGF-2R, InsR-A, InsR/IGF-1R and IGF-1R, insulin can bind InsR and InsR/IGF-1R) [8]