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doi: 10.1016/j.tplants.2010.06.005 23 DuttaS.BasuR.PalA.KunalikaM

Additionally, HIF-1 controls mitochondrial health through modulation of critical genes involved in the mitophagic pathway (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) and BNIP3 L) (Semenza, 2012)

This co-oxidation inevitably compromises diagnostic accuracy [167]

In settings where rapid multiplex molecular testing is available, some practices have found value in increasing diagnostic specificity at the initial visitnot necessarily to change management in every case, but to: Reduce diagnostic ambiguity for both clinician and patient Improve confidence in withholding unnecessary antibiotics Provide clearer guidance on expected disease course Decrease just in case return visits when symptoms persist longer than anticipated Importantly, this approach is not universally necessary