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The inefficient recycling of Se in BAT for the synthesis of selenoproteins, particularly GPX1 and GPX4 which are involved in adaptive thermogenesis, may potentially lead to increased oxidative stress within this tissue, yet is insufficient to curb heat production

This is mechanistically different from GLP-1 receptor agonists like semaglutide or tirzepatide, which are large peptide chains stabilised by complex tertiary structures that degrade slowly even at suboptimal temperatures

Dong S, Xu J, Jia T, Xu M, Zhong C, Yang G, et al

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