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These data raise the possibility that CAR T cells may execute antitumor activity through 2 complementary mechanisms, (a) immediate killing of malignant cells via the release of cytotoxic factors following engagement of CD19 and (b) initiation of a local immune response, which amplifies and sustains the antitumor activity, leading to complete tumor resolution in a subset of patients

Eur Respir J 6 : 13171323 Berry MJ, Banu L, Larsen PR 1991 Type I iodothyronine deiodinase is a selenocysteine-containing enzyme

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Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement