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PubMed, doi:10.3402/fnr.v59.26407

A pivotal shift occurred around 2004 with the discovery of small-molecule E3 ligase ligands [46], culminating in 2008 when Crews team developed the first small-molecule PROTAC targeting AR using an MDM2 inhibitor, formally coining the term PROTAC and establishing its drug-like potential [47]

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In critical situations, the reduction in plasma glutamine concentration affects the redox state and the metabolism of cells of the immune system, resulting in compromised immune response contributing to the development of sepsis