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These cytokines then enhance keratinocyte hyperproliferation and poor differentiation, leads to the PsO plaques

10.3969/j.issn.1001-1978.2020.10.017 72 RatziuV.BellentaniS.Cortez-PintoH.DayC.MarchesiniG

The identification of ER outside their classical CNS regions like the hypothalamus and the pituitary gland justifies their role in controlling different brain functions (Genazzani et al., Estrogen Pathways: Estrogen Receptors, BDNF and Sirtuin 3 Different pathways play a role in the pleiotropic effects of estrogen in the brain