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The requirement for this metabolic reprogramming in dendritic cell activity is evidenced by studies showing that inhibition of glycolysis with 2-deoxyglucose (2-DG) or knockdown of glycolytic inducers [e.g., HIF-1 and alpha enolase (ENO1)], impaired dendritic cell maturation, and subsequent T cell activation (78, 80, 82, 83)

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It has been reported that hypnotics such as diazepam and zolpidem enhance GABAergic inhibitory signaling by prolonging the decay time constant of GABA A receptors in various brain region including thalamus, hippocampus, and neocortex [33,34,57-59]