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Cu,Zn-SODs, antioxidant enzymes, are linked to a number of diseases because they are essential for detoxifying ROS (Figure 5).The most common pathological conditions such as inflammatory bowel disease, obesity and its consequencesdiabetes and hypertensionand chronic obstructive pulmonary disease, have been linked to changes in Cu,Zn-SOD (SOD1 and SOD3) activity and its expression

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Domitrovi R, Jakovac H, Blagojevi G

Prompted by this unexpected finding, we performed DSF analysis of GLT25D1/COLGALT1 samples in the presence of the highly selective Ca 2+ chelating agent ethyleneglycol- bis (-aminoethyl)-N,N,N,N-tetraacetic acid (EGTA), obtaining a folding destabilization profile matching that observed using EDTA (Fig