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In some ways, the lesser degree of obesity and exacerbated metabolic disturbances in these mice resembles the clinical characteristics of Asian patients with T2DM 17,18 , suggesting that Insr P1195L/ +/HFD mice are suitable for investigating the pathophysiology of HFD-sensitive T2DM in humans

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In addition, a selective GIP agonist showed very low effectiveness in reducing weight, while this co-agonist showed synergism in reducing fat mass in obese rodents