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These postmortem results, along with those from the current and our previous study that highlighted a considerable number of differentially serum expressed amino acids between cases and controlsespecially in malessupport the idea that PD is a heterogeneous systemic disease that disrupts metabolic homeostasis across both central and peripheral organs (Costa et al., 2023)

Based on the above limitations and perspectives, it is beneficial to address the question of how metabolic abnormalities develop in AAD in the future, thus determining which pathways are ideal therapeutic targets

Data S1 and S2)

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