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Expectedly, depletion of cystine or inhibition of the Xc- antiporter using synthetic small molecule inhibitors including erastin, sulfasalazine, sorafenib and even excess of glutamate triggered cystine depletion, decreased GSH level and reduced GPX4 activity, culminating in ferroptosis induction

Specifically, the surface of the gastrointestinal tract is covered by a mucous layer about 50450 m thick, with a pore size of about 501800 nm and a negative charge, forming a complex physicochemical barrier ( Chitosan can enhance the transepithelial permeability of anticancer drugs by temporarily opening tight junctions between epithelial cells ( The carboxyl group on the alginate molecular chain can electrostatically interact with the positively charged protein in the colon mucosa to form a hydrophilic adsorption layer (Figure 2B)

doi: 10.1007/978-3-030-10618-8_30-1 364 LvX.DongQ.ZuoZ.LiuY.HuangX.WuW

SP received a grant (INV-059675) from Bill and Melinda Gates Foundation (BMGF) that supported the Commission including salaries for SL, AMM, RB, NC, CG-W, VO, and YW, and travel support for Commission meetings for SHA, PSS, SP, PW, MNM, CC, BC, SL, AMM, MB, RB, NC, CG-W, VO, and YW