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This design supports the statement that FSN-induced microbial state has a transferable therapeutic effect.' Rescue (Sufficiency Support for Key Mediators): Adding butyrate supplement group (adding sodium butyrate to drinking water, 200 mmol/L, 21 days) can restore the level of butyric acid in the body and relieve inflammation, and the content of butyric acid is negatively correlated with inflammation markers (Wen et al., 2025)

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However, repeatedly TMA-positive, but PCR-negative, results on therapy clearly identified patients certain to relapse when treatment was terminated, indicating the presence of low-level clinically relevant viremia

However, this compound can also be absorbed by macrophages during the formation of atherosclerotic plaque, with TMAO molecules binding to specific receptors on the surface of the macrophages, which triggers a series of signaling events inside the cell that activate specific pathways that induce the expression of genes involved in cholesterol metabolism, inflammation, and oxidative stress (77, 78)