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Individuals with certain genetic predispositionssuch as variants in methionine synthase (MTHFR) and cobalamin metabolism pathwaysmay respond more distinctly to B vitamin protocols

Excessive Cu accumulation in the blood was found in the pathogenesis of atherosclerosis

For the researchers, parenteral high-dose thiamine was effective in reversing Parkinsons disease symptoms, that a dysfunction of thiamine-dependent metabolic processes could cause selective neural damage in the centers typically affected by this disease and that Thiamine could have both restorative and [nerve-protecting] action in Parkinsons disease. Source: Costantini, Antonio, Maria Immacolata Pala, Enzo Grossi, Stella Mondonico, Luisa Ercoli Cardelli, Carina Jenner, Sabrina Proietti, Marco Colangeli, and Roberto Fancellu

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