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When symptoms are not severe, doctors typically like to wait to see if the condition subsides on its own

Proc Natl Acad Sci U S A (2018) 115:928893

Estrogen (diethylstilbestrol) was used for medical castration as an alternative to orchiectomy to suppress testosterone levels

Patients who are pregnant or breastfeeding, patients with active malignancy, patients with certain vascular conditions where angiogenesis is a concern, and patients on specific anticoagulants may not be candidates